The village was originally located further west in Agios Spyridon. According to historical sources, the residents fled the settlement three centuries ago due to a cholera pandemic. The name is Latin and appears to be derived from the phrase “porto juno”, which means “new port.” This port was established SE of the ancient village on a nearby beach by the Venetians. A Venetian tower still  marks the port that once was today.

Aside from agricultural and economic pursuits, the people of Portianou have developed a rich intellectual and artistic heritage that has survived to the present day. The Folklore Museum, the Graveyard of the allied soldiers stationed there in 1915 during the Gallipoli battle, the Church of the Conception of the Virgin, as well as the grand mansions can all be found in Portianou.